Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
نویسندگان
چکیده
Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.
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ورودعنوان ژورنال:
- AJNR. American journal of neuroradiology
دوره 19 2 شماره
صفحات -
تاریخ انتشار 1998